| Fixture | Kick-Off | |
|---|---|---|
| Atalanta 2-1 Chelsea | 09/12/2025 20:00:00 | Preds |
| Athletic Bilbao 0-0 Paris SG | 10/12/2025 20:00:00 | Preds |
| Barcelona 2-1 Eintracht Frankfurt | 09/12/2025 20:00:00 | Preds |
| Bayer 04 Leverkusen 2-2 Newcastle United | 10/12/2025 20:00:00 | Preds |
| Bayern Munich 3-1 Sporting CP | 09/12/2025 17:45:00 | Preds |
| Benfica 2-0 Napoli | 10/12/2025 20:00:00 | Preds |
| Borussia Dortmund 2-2 Bodø/Glimt | 10/12/2025 20:00:00 | Preds |
| Club Brugge 0-3 Arsenal | 10/12/2025 20:00:00 | Preds |
| Internazionale 0-1 Liverpool | 09/12/2025 20:00:00 | Preds |
| Juventus 2-0 Pafos | 10/12/2025 20:00:00 | Preds |
| Kairat Almaty 0-1 Olympiakos | 09/12/2025 15:30:00 | Preds |
| Monaco 1-0 Galatasaray | 09/12/2025 20:00:00 | Preds |
| PSV Eindhoven 2-3 Atlético Madrid | 09/12/2025 20:00:00 | Preds |
| Qarabag 2-4 Ajax | 10/12/2025 17:45:00 | Preds |
| Real Madrid 1-2 Manchester City | 10/12/2025 20:00:00 | Preds |
| Tottenham Hotspur 3-0 Slavia Prague | 09/12/2025 20:00:00 | Preds |
| Union Saint-Gilloise 2-3 Marseille | 09/12/2025 20:00:00 | Preds |
| Villarreal 2-3 FC Copenhagen | 10/12/2025 17:45:00 | Preds |
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