| Fixture | Kick-Off | |
|---|---|---|
| Athletic Bilbao - Paris SG | 10/12/2025 20:00:00 | Preds |
| Bayer 04 Leverkusen - Newcastle United | 10/12/2025 20:00:00 | Preds |
| Benfica - Napoli | 10/12/2025 20:00:00 | Preds |
| Borussia Dortmund - Bodø/Glimt | 10/12/2025 20:00:00 | Preds |
| Club Brugge - Arsenal | 10/12/2025 20:00:00 | Preds |
| Juventus - Pafos | 10/12/2025 20:00:00 | Preds |
| Real Madrid - Manchester City | 10/12/2025 20:00:00 | Preds |
| Qarabag - Ajax | 10/12/2025 17:45:00 | Preds |
| Villarreal - FC Copenhagen | 10/12/2025 17:45:00 | Preds |
| Atalanta 2-1 Chelsea | 09/12/2025 20:00:00 | Preds |
| Tottenham Hotspur 3-0 Slavia Prague | 09/12/2025 20:00:00 | Preds |
| Union Saint-Gilloise 2-3 Marseille | 09/12/2025 20:00:00 | Preds |
| Monaco 1-0 Galatasaray | 09/12/2025 20:00:00 | Preds |
| PSV Eindhoven 2-3 Atlético Madrid | 09/12/2025 20:00:00 | Preds |
| Internazionale 0-1 Liverpool | 09/12/2025 20:00:00 | Preds |
| Barcelona 2-1 Eintracht Frankfurt | 09/12/2025 20:00:00 | Preds |
| Bayern Munich 3-1 Sporting CP | 09/12/2025 17:45:00 | Preds |
| Kairat Almaty 0-1 Olympiakos | 09/12/2025 15:30:00 | Preds |
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